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CHEMICAL PATHOLOGY |
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Colleen Harvey, Technical Head
Dr James Davidson, Clinical
Head
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The Chemical Pathology Laboratory of LabPLUS is one of New Zealand's
premier reference laboratories. The extensive range of analytes offered
by the department provides its clients with a service that is focused
and unique.
The department consists of the following sections: Rapid Response,
Specialist Testing (incorporating Endocrinology, Special Techniques and
Trace Metals) and Chromatography (incorporating Toxicology and HPLC).
The experience of its chemical pathologists, scientists and technical
staff provides an in depth clinical interpretation of tests. |
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Sarah Sargon, Section Leader
Pam Wiltshire, Technical Specialist
Lesley Stewart, Technical Specialist
Rengee Moodley, Technical Specialist
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Supervised by a section leader and three technical specialists and supported by skilled
technical staff this section is able to provide a quality service 24
hours, 7 days a week. Based at Auckland City Hospital the
Rapid Response staff are able to support the two major hospitals, Auckland
City Hospital and Starship Children’s Health as well as the Greenlane
Clinical Centre.
This fully automated Chemical Pathology Section uses a variety of
computer interfaced, state of the art equipment to deliver quality
results with quick turn around times. We offer up to 65 general and
specialist chemistries, therapeutic drug analysis, and cardiac and
tumour marker assays. Our turnaround times generally range from 30
minutes to 4 hours from receipt to reporting, depending on the test.
This section processes up to 1500 patients per day.
By continually investigating new automated assays, we strive to
improve our role as a modern quality health care provider.
The Rapid
Response Section is proud to be the only New Zealand
Laboratory taking part in the CDC Lipid Standardisation Programme. By
being involved in clinical studies and by maintaining the expertise to
manage non-routine testing, this section is able to keep abreast of
changes and innovations. |
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Margie Matson,
Section Leader
Linda Henderson, Technical
Specialist |
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The Endocrinology Group
offers both a hormone and tumour marker measurement service and a
consultation service.
The Clinical Head welcomes enquiries about
the tests provided and is available to make clinical comments on the
results for both diagnosis and treatment. Enquiries are also welcomed
regarding research studies using both current assays provided and
development of new assays for clinical research.
The endocrinology group of Lab Plus measures over 30 hormones and tumour
markers used in the diagnosis and monitoring of patients. These assays
may be found in the LabPLUS Test Guide. Broadly the assays
fall into the following clinical diagnostic categories: |
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(a) |
Tumour Marking |
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Ovarian, breast, stomach, gonadal, adrenal and pituitary. |
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(b) |
Adrenal problems: |
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Congenital adrenal
hyperplasia, Addisons disease, adrenal suppression, Conn's syndrome,
Cushing's syndrome etc. |
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(c) |
Gonadal problems: |
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(1) |
Females: |
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Amenorrhoea and menstrual
disturbances, menopause, hirsutism, and infertility |
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(2) |
Males: |
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Impotence, gynaecomastia |
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(d) |
Pituitary problems: |
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Hypopituitarism,
galactorrhoea and amenorrhoea |
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(e) |
Stature problems (short/tall) |
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Dr
Roger Johnson, Scientific Officer
Tony Marcinkowski, Technical Specialist |
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| The Special Techniques
Section generally undertakes tests where the demand for them can be
variable including but not limited to porphyrins, sweat tests,
examination of renal calculi, blood and plasma cholinesterase, and
faecal chymotrypsin. Although many assays are performed by traditional
manual procedures, automated modern technology is used where possible.
The evaluation of glucose meters is also provided here. |
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Barry Palmer, Scientific Officer |
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The Trace Metals Section is
supervised by a Scientific Officer and specialises in the measurement of
trace elements by utilising inductively coupled plasma mass spectrometry
(ICP-MS) technology.
This technique allows measurements to be made on a range of sample types
including whole blood, serum, plasma, urine and liver biopsy samples,
where specimen requirements depend on the element to be analysed.
The analysis of essential trace elements is not only important in
dietary monitoring, but also aids in the clinical assessment of disease
status (i.e. Wilson's Disease). The measurement of non-essential trace
elements, including lead and mercury, plays an important role in
poisoning detection, as well as monitoring occupational exposure.
Participation in Australian based external survey programmes ensure that
quality results to industry standards are provided. The continual review
of new techniques and assays allow for improvement to the existing
service. |
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Gopyraj Sundararajah, Section
Leader
Ayka Hammer-Plecas, Technical Specialist
Dr Hima Madhavaram,
Scientific Officer
Dr Ron Couch, Scientific Officer Toxicology
Dr Gerald Woollard, Scientific Officer HPLC |
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| The Chromatography Section of Chemical Pathology offers a wide range of
specialist services. Chromatography Section consists of
Toxicology, Workplace Drug Testing, and HPLC disciplines. The
section is managed by a section leader, three scientific officers and a
technical specialist. The section operates from 8am to 5pm Monday
to Friday for routine work and is available for urgent work 24 hours, 7
days a week.
Chromatography Section uses the following instrumentation/techniques to
provide an appropriate high quality service:
Gas chromatography-mass
spectrometry (GC-MS)
Gas chromatography-thermionic detection (GC-NPD)
Gas chromatography-head space analysis
High pressure
liquid chromatography - photodiode array detection
High pressure
liquid chromatography - UV and fluorescence detection
High pressure
liquid chromatography - Electrochemical detection
Automated enzyme immunoassay
Fluorescence polarization immunoassay
Thin layer chromatography (TLC)
Solid phase extraction (SPE)
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Therapeutic Drug Quantification
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| Antiarrythmics |
Antibiotics |
| Anticonvulsants |
Analgesics |
| Antidepressants |
Immunosuppressives |
| Antipsychotics |
Antineoplastic |
| Antiasthmatics |
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Overdose Drug Screen
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| Analgesics (narcotic and
non-narcotic) |
Antihypertensives |
| Antianxiety agents |
Antimalarials |
| Antiemetics |
Central stimulants |
| Antidepressants |
Hallucinogens |
| Antihistamines |
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Other HPLC tests
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| Fat soluble vitamins |
| Phorphrin identification |
| Biogenic amines |
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The following screens must be requested
specifically
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| Glycolic Acid Screen |
| Sulphonylurea Serum Screen |
| Laxative Abuse Screen |
| Cotinine Urine Screen |
| Volatile Alcohol Screen - methanol, ethanol, propanol,
isopropanol, butanol |
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Narcotic/Illicit Drug Screen
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| The requestor should be as specific as
possible as to what drug/drug group is required to be
investigated. |
| See our LabPLUS Test Guide |
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Workplace and Employment Drug
Screen
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| We can offer appropriate urine specimen
collection kits and chain of custody documentation.
Urine specimens collected for this type of screening should
not be forwarded as typical clinical specimens since legal
implications may be involved. |
| See our
Drug Testing site. |
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